Vidisha Tripathi, 1 Zhen Shen, 1 Arindam Chakraborty, 1 Sumanprava Giri, 1 Susan M. Freier, 2 Xiaolin Wu, 3 Yongqing Zhang, 4 Myriam Gorospe, 5 Supriya G. Prasanth, 1 Ashish Lal, 6 and Kannanganattu V. Prasanth 1 , *
Vidisha Tripathi
1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Zhen Shen
1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Arindam Chakraborty
1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Sumanprava Giri
1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Susan M. Freier
2ISIS Pharmaceuticals, Carlsbad, California, United States of America
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Xiaolin Wu
3Laboratory of Molecular Technology, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
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Yongqing Zhang
4Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Myriam Gorospe
5Laboratory of Molecular Biology and Immunology, National Institute of Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Supriya G. Prasanth
1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Ashish Lal
6Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Kannanganattu V. Prasanth
1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Bruce E. Clurman, Editor
Author information Article notes Copyright and License information Disclaimer
1Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
2ISIS Pharmaceuticals, Carlsbad, California, United States of America
3Laboratory of Molecular Technology, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
4Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
5Laboratory of Molecular Biology and Immunology, National Institute of Aging, National Institutes of Health, Baltimore, Maryland, United States of America
6Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Fred Hutchinson Cancer Research Center, United States of America
* E-mail: ude.sionilli.efil@pramuk
SMF is an employee of Isis Pharmaceutical, receives salary from the company, and holds stock options. The other authors have declared that no competing interests exist.
Conceived and designed the experiments: VT KVP. Performed the experiments: VT ZS SG AC XW YZ. Analyzed the data: VT KVP XW YZ MG AL SGP. Contributed reagents/materials/analysis tools: SMF. Wrote the paper: KVP VT.
Received 2012 Aug 24; Accepted 2013 Jan 21.
Copyright © 2013 Tripathi et al
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Associated Data
Supplementary MaterialsFigure S1: MALAT1 levels are cell cycle regulated and depletion of MALAT1 results in proliferation defects. [A] MALAT1 and Cyclin E levels in 10 and 15 hr post release serum-starved WI-38 cells are analyzed by qRT-PCR. Note that the MALAT1 levels increased during G1/S phase [G1/S is determined by the increased levels of cyclin E]. Mean ± SEM, *p